The Runaway Guys Colosseum is an annual charity event that is live streamed over Twitch that supports Direct Relief. It is hosted on ProtonJon's Twitch channel, and individual videos are re-uploaded to TheRunawayGuys YouTube channel, similar to Stephen and Mal's Extra Life videos. Stephen and Mal joined the first event from May 4, 2018 to May 6, 2018 along with many other guests:
- Adriana Figueroa
- Proton Jon
- Stephen Georg
- The Lamp
- Tom Fawkes (Lord Dona'tor)
The 2018 live event was able to gather over $111,492 during the live stream, and $112,610 in total.
The third event (known as The Runaway Guys Colosseum Direct) was a remote-only iteration of the event which ran from April 17, 2019 to April 19, 2020. Along with the combined cast from the first two Colosseums, the following people joined the event and participated in segments as part of The Runaway Guys family:
- Corey Dyer
In spite of the constraints the event was under, the Direct ended up breaking donation records from the previous two Colosseums, ending the marathon at a grand total of over $230,000.