The Runaway Guys Colosseum is an annual charity event that is live streamed over Twitch that supports Direct Relief. It is hosted on ProtonJon's Twitch channel, and individual videos are re-uploaded to TheRunawayGuys YouTube channel, similar to Stephen and Mal's Extra Life videos. Stephen and Mal joined the first event from May 4, 2018 to May 6, 2018 along with many other guests:
- Proton Jon
- Stephen Georg
- Tom Fawkes (Lord Donator)
The 2018 live event was able to gather over $111,492 during the live stream, and $112,610 in total.